The show featured the star's greatest hits and signature choreography, telling the story of her lengthy career.

12/31/2025

Jennifer Lopez performs during the debut of her Las Vegas residency at The Colosseum at Caesars Palace on December 30, 2025 in Las Vegas, Nevada. Denise Truscello/Getty Images for Live Nation Las Vegas

As soon as the curtain fell in 2018 on her 120-show $100 million-grossing Jennifer Lopez: All I Have residency at Planet Hollywood, the speculation began on when — not if — J.Lo would return to Las Vegas.

After seven years, she announced plans for the new Up All Night Live while hosting the American Music Awards in May 2025. On Dec. 30, after months of rehearsal and teasers on her social media, the fervor came to fruition, as Lopez transported the sold-out audience of more than 4,000 at The Colosseum at Caesars from fantasy to reality and back again in a feverish haze of gyrating bodies and miles of sequins.

Always known for making a major entrance, Lopez launched the 120-minute pop, R&B and Latin music and dance odyssey with a spectacular Broadway-themed opener that included “Let Me Entertain You” from the musical Gypsy; 1999’s “Waiting for Tonight” mashed-up with West Side Story’s “Mambo”; an ultra-jazzy “Jenny From the Block”; and finished with 2007’s “Do It Well.”

This set the tone for a night where Lopez framed her best moments not as a greatest hits revue but as a living timeline of “J.Lo the artist” chronicled through music, choreography and costuming. In a toast to their early aughts reign as the terry-cloth sweatsuit king and queen, Ja Rule joined Lopez on stage for their hits “Ain’t It Funny” and “I’m Real.”

The most significant difference from her last Vegas show? Lopez’s participation in Up All Night Live as narrator, speaking candidly about reinvention, resilience and the discipline it has taken to get her here and back again. Those reflections gave emotional ballast to the high-gloss production designed for spectacle on Las Vegas’ most storied stage, which Adele, Cher, Mariah Carey and Celine Dion have graced.

Here’s a look at Lopez’s full opening night setlist for Up All Night Live at The Colosseum at Caesars Palace.

• ACT 1

• “Let Me Entertain You” from ‘Gypsy’

• “Waiting for Tonight”/”Mambo” from ‘West Side Story’

• “Jenny From the Block”

• “Do It Well”