More heartbreak for Caroline Kennedy after daughter Tatiana Schlossberg's cancer death aged just 35: Dad JFK was murdered, only sibling JFK Jr. was killed in plane crash and mother Jackie died of lymphoma aged 64
The death of Tatiana Schlossberg marks the latest in a 60-year series of tragedies for her mother Caroline Kennedy.
The death of Caroline Kennedy's 35-year-old daughter Tatiana Schlossberg from cancer leaves John F. Kennedy's only surviving child facing yet another tragedy in a life beset by heartache.
Kennedy, 68, was just five years old when her father died from an assassin's bullet during a presidential motorcade in Dallas, Texas, in 1963.
Five years later, her uncle Robert Kennedy too would die tragically, assassinated while campaigning for president in Los Angeles in 1968.
in 1994 she lost her mother, Jacqueline Kennedy Onassis, to lymphoma at age 64.
The so-called 'Kennedy curse' reared its head yet again with the death of her brother, John F Kennedy Jr., in 1999.
JFK Jr, who was Caroline's only sibling, died when a small plane he was piloting crashed near Martha's Vineyard. He was only 38. His wife, Carolyn Bessette-Kennedy also perished in the crash alongside her sister Lauren.
The incident left Caroline the only remaining survivor of President Kennedy's immediate family, and after years of heartbreak, she elected to not hold a public memorial service.
Instead, she scattered his ashes into the stretch of the Atlantic off the coast of Martha's Vineyard where their father met his fate.
At the time, Caroline was only 41. She was in the midst of building her own family, with longtime husband and Manhattan artist Edwin Schlossberg.
Tatiana Schlossberg (left), passed away Tuesday morning at age 35, weeks after revealing she was diagnosed with terminal cancer last year. She is seen with her mother Caroline Kennedy in Manhattan as a teen in 2006
Kennedy - a former US diplomat - is seen here with (l-r) sister-in-law Carolyn Bessette-Kennedy, brother JFK Jr, and husband Edwin Schlossberg. Both her brother and Bessette-Kennedy died in their 30s during a plane crash in 1999
Kennedy also lost her mother, Jacqueline Kennedy Onassis, to lymphoma at age 64. She is seen alongside her brother at their mother's 1994 funeral
After marrying in 1986, the two welcomed three children: Rose Schlossberg, 37; Tatiana, and youngest Jack, who is 32.
Tatiana would later become a successful journalist, writing for publications like The New York Times, The Atlantic, The Washington Post, Vanity Fair, and Bloomberg over the years.
Her mother, meanwhile, was named the US's ambassador to Japan by then-President Barack Obama - a position she held until Donald Trump's first term. She also served on both of Obama's election campaigns.