Viruses and bacteria are often viewed as harmful, but researchers at Flinders University are drawing attention to a lesser-known side of the microbial world. Their work highlights the important ways microbes can support human health, challenging the idea that all microorganisms are threats.

Flinders microbial ecologist Dr. Jake Robinson and his colleagues explore this shift in a new paper published in Microbial Biotechnology. The research encourages moving beyond a fear-based view of microbes and biogenic compounds and instead recognizing their potential health benefits.

A New Database of Health-Promoting Microbes

The study introduces the 'Database of Salutogenic Potential', a first-of-its-kind, open-access prototype that gathers information on microbes and natural compounds linked to positive health outcomes. The goal is to make this growing body of evidence easier to access and apply.

"Emerging evidence shows that exposure to diverse environmental microbiomes and natural biochemical products also promotes health and resilience," says Dr. Robinson.

"Rather than viewing biodiversity as something to be eliminated, contemporary approaches recognize the vital role of diverse ecosystems in creating salutogenic, or health-promoting, environments."

Moving Beyond a Disease-Focused View

By bringing this information together, the researchers aim to change how microbes are understood. "By consolidating this data, we aim to rebalance the story of microbes -- highlighting not only what makes us sick, but also what keeps us well. After all, health is not merely the absence of disease."

"The implications are far-reaching -- from designing healthier cities and schoolyards to guiding ecosystem restoration and rethinking green infrastructure."

Despite their importance, salutogenic microbes, meaning those that support health, and beneficial biochemical compounds have received far less attention than disease-causing organisms. Yet they play key roles in immune regulation, metabolism, disease suppression, stress reduction, and ecosystem stability.

Why Beneficial Microbes Have Been Overlooked

"For well over a century, microbes and chemicals in the air have mainly been studied as threats -- causes of infection, disease and contamination. While this pathogen-centric lens has saved countless lives, it also risks overlooking the invisible biodiversity that actively supports human and planetary health," says Dr. Robinson.

"Just as biodiversity loss threatens our health, restoring microbial and biochemical richness could be a key to healthier futures."

Key Findings and Future Applications

The team identified 124 microbial taxa with potential health-promoting effects, along with 14 biochemical compounds (from soil bacteria to plant-derived phytoncides). These are linked to benefits that include immune system support and reduced stress.